DNA-tests en biologische veroudering
Epigenetic clocks, telomere length and their role in preventive medicine
The Linus Pauling Prevention Center (LPPC) focuses on the science-based approach to aging. In doing so, we look beyond calendar age: we focus on biological age. Thanks to recent breakthroughs in epigenetics and molecular diagnostics, we can measure, and even influence, this biological age with increasing precision.
Epigenetic clocks: measuring how fast you age
Epigenetic clocks are tests that analyze DNA methylation patterns – chemical changes on DNA that regulate gene expression without changing the genetic code itself. These patterns change predictably with age, forming a “biological clock.
The DunedinPACE Clock
One of the most advanced epigenetic clocks is the DunedinPACE (Pace of Aging Computed from the Epigenome). Unlike other clocks that estimate biological age, this clock measures the rate at which a person ages – a dynamic measure that correlates strongly with risk of disease, functional decline and premature death.
– Normal: an aging rate of 1.0 (1 biological year per calendar year)
– Accelerated: >1.0 (faster biological wear and tear)
– Delayed: <1.0 (aging slower than average)
Thus, this test is not only a snapshot, but also a prognostic tool. This makes it ideal for follow-up within a preventive and lifestyle approach.
Telomere length: biological wear at the cellular level
An additional biomarker is telomere length. Telomeres are protective ends of our chromosomes that shorten slightly with each cell division. Short telomeres are associated with increased risk of chronic disease, immunosenescence and shortened lifespan. Although telomere length fluctuates and is less precise than epigenetic clocks, it remains an important indicator of cellular aging and regenerative potential.
Relevance within the LPPC
At the LPPC, epigenetic clocks and telomere measurements are integrated into the preventive consultation model, with a focus on:
– Early detection of accelerated biological aging
– Monitoring interventions: lifestyle changes, nutritional interventions, bioactive substances (bioceuticals), stress management
– Personalized advice based on measurable parameters
– Motivational communication: patients gain insight into their internal aging process and are encouraged to actively adjust it
Treatment and modulation of aging
Based on these measurements, we develop a personalized treatment plan, which may include:
– Orthomolecular supplementation aimed at supporting DNA repair, mitochondrial function and methylation processes
– Nutrition: anti-inflammatory and epigenetically beneficial diets (including polyphenols, omega-3, sulforaphane)
– Exercise: adapted to biological age and functional reserves
– Sleep optimization: regulation of circadian gene expression
– Stress reduction and psychoneuroimmunological balance
– Time-controlled diet/fasting mimicking diets, if indicated
– Follow-up via repeated measurements (e.g., after 6 or 12 months)
The LPPC aims to translate scientifically validated biomarkers of aging into concrete therapeutic choices within an ethical and forward-looking medical framework.