Biogerontology & Anti-Aging at the Linus Pauling Prevention Center

At the Linus Pauling Prevention Center (LPPC), we approach aging not as an inevitable decline, but as a biologically modifiable process. This view is rooted in biogerontology, the branch of science that investigates the mechanisms of aging and looks for ways to slow, modulate or even partially reverse the aging process.

The focus is not on aesthetics, but on prolonging the health span – the years during which one remains active, functional and free of chronic disease.

Gaining sight of the invisible, before illness becomes visible

As a physician, I combine insights from biogerontology with clinical experience and practical applicability. Within the LPPC, we translate basic research into personalized medical strategies aimed at:

  • reducing biological aging rate
  • delaying age-related diseases (such as cardiovascular disease, cancer, neurodegeneration)
  • optimizing metabolic and cellular resilience
  • improving immune balance and inflammation control
  • promoting mitochondrial and epigenetic health

Key elements of our biogerontological approach

1. Lifestyle interventions as biological modulators.

Nutrition, exercise, sleep, stress management and social connectedness are powerful influencing factors on gene expression, inflammation, telomere maintenance and mitochondrial function.

2. Orthomolecular concept and nutritional medicine.

Aimed at restoring biochemical balance and supporting metabolic pathways involved in aging, oxidative stress and cell renewal.

3. Use of geroprotectors and senolytics

Farmacologische middelen met potentieel verouderingsremmende of celvernieuwende werking (zoals metformine, rapamycine, dasatinib, quercetine en acarbose), onder strikt medisch toezicht en op basis van risicoanalyse.

4. Epigenetic diagnostics and clocks

Objective evaluation of biological age via DNA methylation patterns (e.g. Horvath, PhenoAge, GrimAge clocks) allows for mapping the effect of interventions on cellular aging.

5. Preventive imaging and biomarker analysis.

We use techniques such as whole-body MRI, coronary calcium score, DEXA and comprehensive laboratory analysis of aging-related markers to monitor health and make timely adjustments.

Ethics, precision and personalization

Each intervention at the LPPC starts from an individualized care pathway based on thorough analysis, comprehensive history and informed decision making. The anti-aging medicine we practice is ethical, scientifically based and free from commercial influence.

Biogerontology as medical field of the future

In the coming decades, medicine will increasingly focus on functional aging and preventive modulation of disease processes. At the LPPC, we are already putting this vision into practice today, with an eye for scientific foundation, personal context and societal added value.